AAA+ Ring and Linker Swing Mechanism in the Dynein Motor

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AAA+ Ring and Linker Swing Mechanism in the Dynein Motor

Dynein ATPases power diverse microtubule-based motilities. Each dynein motor domain comprises a ring-like head containing six AAA+ modules and N- and C-terminal regions, together with a stalk that binds microtubules. How these subdomains are arranged and generate force remains poorly understood. Here, using electron microscopy and image processing of tagged and truncated Dictyostelium cytoplasm...

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ATP-Driven Remodeling of the Linker Domain in the Dynein Motor

Dynein ATPases are the largest known cytoskeletal motors and perform critical functions in cells: carrying cargo along microtubules in the cytoplasm and powering flagellar beating. Dyneins are members of the AAA+ superfamily of ring-shaped enzymes, but how they harness this architecture to produce movement is poorly understood. Here, we have used cryo-EM to determine 3D maps of native flagellar...

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ژورنال

عنوان ژورنال: Cell

سال: 2009

ISSN: 0092-8674

DOI: 10.1016/j.cell.2008.11.049